I'm just, duh, realizing what I'm sure everyone else already knows: House is Sherlock Holmes. It took the new Sherlock, with his aggravating ways, for the obvious to knock me down. Brilliant, addictive, sarcastic and abrasive, condescending to his best friend who nevertheless supports and aids him through the worst, and always, always right. I'm sure there are articles if not books on this.

ETA: There's certainly a Wikipedia entry on this.
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